| abstract |
The invention provides N-propionylsarcosineanilides of the formula: ##STR1## wherein n is an integer of 1 to about 3 and the substituent A which can be the same or different when n is greater than 1 is selected from the group consisting of trifluoromethyl; halogen; nitro; acetyl; a straight-chain or branched alkyl group having 1 to 4 carbon atoms; a straight-chain or branched alkoxy group having 1 to 4 carbon atoms; a straight-chain or branched alkylmercapto group having 1 to 7 carbon atoms; a substituted alkylmercapto group of the formula: ##STR2## wherein n is an integer of 1 or 2, R 1 can represent hydrogen and methyl, and R 2 can represent hydroxyl, and an amino group of the formula: n n --NR.sub.6 R.sub.7 V n n wherein R 6 can represent hydrogen, and methyl, and R 7 can represent methyl, substituted benzyl, and R 6 and R 7 , together with the nitrogen, can constitute a substituted pyrrolidine ring; a sulphonyl group of the formula: n n --SO.sub.2 R.sub.3 III n n wherein R 3 can represent amino, and alkyl of 1 to 3 carbon atoms; or an aminoethoxycarbonyl group of the formula: ##STR3## wherein R 4 and R 5 which can be the same or different can represent hydrogen, methyl, and ethyl; and the pharmaceutically acceptable salts thereof. These compounds may be made from N-propionylsarcosine and the corresponding substituted anilines. They have central vaso-active properties, are useful in controlling metabolism, inhibit the aggregation of thrombocytes, can be used for the treatment of the cerebroischaemic and atrophic type, and have tranquillizing properties. |