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filingDate 1980-09-30^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1982-11-16^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a015f061d4e6c9b9b75f54647d016c9c
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publicationDate 1982-11-16^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4359457-A
titleOfInvention Anti Thy 1.2 monoclonal antibody-ricin hybrid utilized as a tumor suppressant
abstract A tumor suppressive composition active against lymphoma consisting of an injection of hybrid protein anti Thy 1.2 monoclonal antibody-ricin and hyperosmotic lactose. The inoculation i.v. of murine tissues in vivo by lymphoma is made at -20 to -25 days and the tumor suppressant composition is used i.v. at Day 1 in an amount of 1-3 μg of anti Thy monoclonal antibody-ricin together with sufficient hyperosmotic lactose to raise the lactose level to 20-30 mM. The broad purpose of this invention is to modify the receptor specificity of a potent toxin such as ricin by coupling it with a monoclonal antibody directed at a specific tumor or differentiation antigen. The object here is to use the reagent to selectively kill tumor cells without affecting normal cells.
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