http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4382929-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate | 1980-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-05-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_964aa1841dbe223cd0406120c1725857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09d695d998d309cfb4b64324c05b3564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81fe9984a7bc6171b3f87be46ea8e773 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ae061ab3f7cd8ad11023fb614b4fa07 |
| publicationDate | 1983-05-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4382929-A |
| titleOfInvention | Thiophene derivatives and their pharmaceutical compositions and method of use |
| abstract | The invention provides compounds of the general formula (I) <IMAGE> (I) and physiologically acceptable salts, hydrates and bioprecursors thereof, in which one of R1 and R2 represents hydrogen, halogen or a C1-4 alkyl group which may be optionally substituted by hydroxy or C1-4 alkoxy, and the other represents the group R4R5NAlk- in which R4 represents hydrogen, C1-10 alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heteroaralkyl, trifluoroalkyl, or alkyl substituted by hydroxy, alkoxy, amino, alkylamino, dialkylamino or cycloalkyl, and R5 represents hydrogen or a C1-4 alkyl group or R4 and R5 may, together with the nitrogen atom to which they are attached, form a 5 to 10 membered ring which may be saturated or may contain at least one double bond, may be unsubstituted or may be substituted by one or more C1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom selected from oxygen and sulphur; Alk represents a straight or branched alkylene chain of 1 to 6 carbon atoms; R3, which may be in either the 2 or 3-position, represents the group <IMAGE> where X represents -CH2-, -O- or -S-; n represents zero, 1 or 2; m represents 2, 3 or 4; and where Y represents S, O, CHNO2 or NR7 where R7 is nitro, cyano, alkylsulphonyl or arylsulphonyl; R6 represents hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl or aralkyl; with the provisos that where R2 represents the group R4R5NAlk then R3 is in the 2-position; and where R2 represents hydrogen then R3 is in the 3-position. The compounds of formula (I) show pharmacological activity as selective histamine H2- antagonists. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5015656-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6069258-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5158971-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022034121-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5834460-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4923882-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4738983-A |
| priorityDate | 1979-10-23^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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