| abstract |
Novel syn isomers of 7-amino-thiazolyl-acetamido-3-acetoxymethyl-cephalosporanic acid derivatives of the formula <IMAGE> I wherein R1 is selected from the group consisting of -CN, -CONH2 and -COOR1', R1 ' is selected from the group consisting of alkyl of 1 to 3 carbon atoms, hydrogen, alkali metal, alkaline earth metal, ammonium, magnesium and a non-toxic, pharmaceutically acceptable organic amine, A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, ammonium, magnesium and a non-toxic, pharmaceutically acceptable organic amine, R' and R'' are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms with the <IMAGE> group in the syn position with the proviso that when R1 is -COOR1 ' and R1 ' is hydrogen, A is hydrogen and when R1 is -COOR1 ' and R1 ' is an alkali metal, alkaline earth metal, magnesium, ammonium or an organic amine, A is an alkali metal, alkaline earth metal, magnesium, ammonium or an organic amine having antibiotic properties and novel intermediates and processes. |