http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4405790-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11c60609cb0d322050213a376ea65ae2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-73 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 |
| filingDate | 1982-04-08^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c94fe526deb985807a7c394b6b3d8cea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0744401edf36f1cf2f95ed2d5f4011cb |
| publicationDate | 1983-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4405790-A |
| titleOfInvention | Process for preparing 2-alkylamino- and 2-amino-5-alkylpyridines |
| abstract | An improved process for preparing the 2-alkylamino-5-alkylpyridine and 2-amino-5-alkylpyridine amination products of 3-alkylpyridines, comprising the step of initially reacting the base directly with the sodium salt of a primary alkylamine to produce the 2-alkylamino form, wherein the alkyl group in each reactant has from 1 to about 20 carbon atoms. The sodium salt is preferably preformed in situ by adding the alkylamine to a dispersion of sodium in an organic solvent heated to about 100 DEG -120 DEG C. The substituted amination preferably proceeds at a temperature of about 100 DEG -140 DEG C. in a solvent such as toluene and under an inert nitrogen atmosphere. The ratio of 2,5-:2,3- isomer products of the reaction is up to about 10:1 or more, with the effective yield of the 2,5-alkylated isomer being about 25% or more. This recovered 2-alkylamino-5-alkylpyridine product is readily dealkylated by reaction with hydrobromic or hydriodic acid with or without the presence of a pyridine hydrohalide salt to obtain the 2-amino-5-alkylpyridine product which has proven uses in herbicidal, insecticidal and pharmaceutical applications. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5332824-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0569701-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9600216-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7323474-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106496105-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106496105-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004209894-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4652650-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5808081-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111778720-A |
| priorityDate | 1982-04-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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