| abstract |
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula <IMAGE> wherein R and R1 are independently selected from hydrogen, lower alkyl or alkoxyalkyl groups; R2 is lower alkyl, aryl, or hetaryl; R3 is cycloalkyl, aryl or hetaryl, generally with electron-withdrawing substituents; R4 is lower alkyl, alkoxyalkyl, aminoalkyl, haloalkyl, or dialkylaminoalkyl; R5 is lower alkyl or aryl; m is 0 or 1; and n is 0, 1, or 2. Compounds of this series demonstrate blockage of calcium ion flux in tissue preparations in vitro and vasodilation in animal testing in vivo. |