| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a22da5b7dd6ed60a21538e5edb23e051 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-222 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-645
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-10 |
| filingDate |
1983-09-06^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1985-12-31^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fab60738403efc2a4d13e56a6b8ad25 |
| publicationDate |
1985-12-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4562151-A |
| titleOfInvention |
Stabilization of L-phenylalanine ammonia-lyase enzyme |
| abstract |
A process for the synthesis of L-phenylalanines and analogues thereof from trans-cinnamate, ring substituted trans-cinnamates or various acrylate derivatives and ammonia or an ammonia donor in the presence of L-phenylalanine ammonia-lyase enzyme and a desensitizing agent such as polyhydric alcohols and polyethylene glycol-(400) is disclosed. The process embraces the discovery that compounds such as polyhydric alcohols and polyethylene glycol-(400) desensitize the L-phenyalanine ammonia-lyase enzyme to substantially higher substrate concentrations than practiced heretofore. In addition, polyhydric alcohols and polyethylene glycol-(400) substantially enhance the instantaneous rate of reaction and inhibit inactivation of the L-phenylalanine ammonia lyase enzyme over longer reaction periods. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5981239-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009047268-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1737968-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7560263-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1737968-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008008695-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7537923-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7790433-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010278802-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7553653-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7531341-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7534595-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2280075-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011012632-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9546361-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008032371-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008008179-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10221408-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008008179-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7153502-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0902289-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4755466-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9557340-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007048855-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0902289-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1085095-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0216630-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009263369-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11505790-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011201022-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8569036-B2 |
| priorityDate |
1983-09-06^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |