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filingDate 1985-03-18^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1987-06-16^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4673763-A
titleOfInvention Alpha-functionalized derivatives and labeled conjugates of procainamide and NAPA
abstract Procainamide and N-acetylprocainamide (NAPA) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining the respective drugs. The immunogens comprise the drugs coupled at the alpha -position of the amide side chain to an immunogenic carrier material. The labeled conjugates and synthetic intermediates similarly are alpha -position derivatives of the drugs or precursors thereof. The antibodies and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring the respective drugs in biological fluids such as serum.
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