| abstract |
PCT No. PCT/SE85/00020 Sec. 371 Date Aug. 29, 1985 Sec. 102(e) Date Aug. 29, 1985 PCT Filed Jan. 18, 1985 PCT Pub. No. WO85/03287 PCT Pub. Date Aug. 1, 1985.A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase (PGDH) and having the formula <IMAGE> (I) in which R1 and R2 are hydrogen or lower alkyl; R3 is hydrogen, lower alkyl or substituted or unsubstituted phenyl; R4, R5, and R6 are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R4 to R6 being hydrogen; R7 to R11 are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R8 and R10 may in addition be carboxy; at least two of R7 to R11 always being hydrogen; and -A- is -CO-, -CH2-CO-, -CH=CH-, -CH=CH-CO- or corresponding groups in which a hydrogen atom is replaced by a lower alkyl group. The invention comprises also lactones of those compounds in which R1 is hydrogen, and salts of those compounds which contain at least one carboxy group. |