| abstract |
Vasopressin antagonists which have a dipeptide tail composed of a neutral and basic amino acid unit demonstrate potent V1 and V2-antagonist activity. Two species of this invention, which are prepared by solid phase peptide synthesis, are [1-( beta -mercapto- beta , beta -cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-tyrosine-8-arginine-9-desglyci ne]-vasopressin and [1-( beta -mercapto- beta , beta -cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-tyrosine-9-desglyci ne]-vasopressin. |