| abstract |
New 1-phenyl-2-aminocarbonylindole compounds are described which have the general formula I <IMAGE> I where R1 is a hydrogen atom, or a lower alkyl, alkenyl, cycloalkylalkyl radical, R2 is a hydrogen atom or a lower alkyl radical, R3 is a hydrogen or halogen atom, or a lower alkyl, hydroxyl or lower alkoxy radical, R4 is a hydrogen or halogen atom, or a lower alkyl, hydroxyl or lower alkoxy radical, or, if R3 is a hydrogen atom, R4 may be a nitro or trifluoromethyl radical, or R3 and R4 together denote a methylenedioxy or ethylenedioxy radical, R5 has the meanings given for R3, R6 has the meanings given for R4, R7 is a hydrogen atom or, if R5 and R6 are lower alkoxy radicals, R7 may also be a lower alkoxy radical, R8 and R9 are each a hydrogen atom or a lower alkyl radical or, together with the nitrogen atom, form a heterocyclic group, and Z is an alkylene chain which is optionally substituted by hydroxyl. The compounds have pharmaceutical properties, in particular antiarrhythmic properties. The compounds may be in the form of the free bases or acid addition salts. Pharmaceutical compositions containing these compounds are described as is a method of preparing them. Valuable intermediates for the production of these compounds and methods of preparing the intermediates are also described. |