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publicationDate 1989-07-25^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4851511-A
titleOfInvention Monoclonal antibody that specifically binds to disialosyl Lea
abstract Disialosyl Lea (IV3NeuAcIII6NeuAcIII4FucLc4), a novel human cancer-associated fucoganglioside that is highly immunogenic. Also, a hybridoma cell line (ATCC No. HB 8861)secreting a monoclonal IgG3 antibody (FH7) directed to disialosyl Lea. The disialosyl Lea antigen was detected in various cancer tissues and their cell lines but was absent in various normal tissues and blood cells. Sera of patients with various cancers, particularly early cases of colonic and gastric cancers, showed an elevated disialosyl Lea antigen level, which subsequently decreased after surgical tumor removal.
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