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filingDate 1987-11-16^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1990-04-03^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcd9549b9e449de99c644825e629830f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf4e66069be60543a9e62f1c2226c3e8
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publicationDate 1990-04-03^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4914188-A
titleOfInvention Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
abstract Novel cyclosporin analogs containing a MeAla or MeAbu residue at the 6-position of the cyclic undecapeptide have been synthesized and found unexpectedly to exhibit antagonistic activity toward cyclosporin A binding to its cytosolic protein receptor, cyclophilin, without being immunosuppressive.
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