| abstract |
A chemical composition for electrolytic transdermal transport of a protein to the blood stream of the patient comprises: (a) a protein, (b) a cosolvent with negative Setschenow constants, and (c) water. Some of the preferred proteins are: insulin, protamine sulfate, calcitonin, glucagon, and corticotropin. Some of the preferred dissociating agents with negative Setschenow constants are: urea, propylurea, potassium iodide, sodium perchlorate, and guanidine hydrochloride. The electrolytic device containing the composition to be transdermally delivered comprises: two electrode elements separated by barrier means, a reservoir containing the composition of the invention, an electronic/electrolytic circuit including a source of a power, a cover, and adhesive means holding the device to the patient's skin. A semipermeable membrane between the patient's skin and the electrolytic device is optional. |