| abstract |
The invention relates to derivatives of nucleosides and their use for the synthesis of oligonucleotides. These derivatives are in accordance with the formula: <IMAGE> (I) in which B represents a radical derived from guanine, cytosine or adenine, whose exocylic NH group is protected by the group <IMAGE> with R1 representing a hydrogen atom or an alkyl radical and R2 a hydrogen atom, and alkyl radical, an alkoxy radical and optionally substituted aryloxy radical, R3 represents a hydrogen atom, the dimethoxytrityl radical or the radical <IMAGE> R4 represents a hydrogen atom, the radical of formula: <IMAGE> or a radical suitable for the synthesis of polynucleotides and R5 represents a hydrogen atom or the protected or unprotected hydroxyl OH radical. |