| abstract |
Substituted benzyl ethers, benzyl thioethers, and benzylamines of the formula <IMAGE> (I) in which R1 and R2 are identical or different and represent hydrogen, alkyl, alkenyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, sulphonylalkyl, halogenoalkoxy, halogenoalkylthio, aralkoxy, aralkylthio, halogen, nitro, cyano or hydroxyl, or represent a group of the formula <IMAGE> wherein R4 and R5 are identical or different and represent hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl or acyl, R3 represents a group of the formula <IMAGE> <IMAGE> in which R6 represents hydrogen, alkyl or acyl, R7 represents hydrogen or alkyl and n represents a number from 3 to 10, B represents -CH2-X- or -X-CH2-, wherein X represents O, S or NR7, and wherein R7 has the abovementioned meaning and the group <IMAGE> represents a benzo-fused heterocyclic system, A in the heterocyclic radical being 3-, 4- or 5-membered and containing nitrogen, oxygen and/or sulphur as hetero-atoms. These compounds are lipoxygenase inhibitors. |