http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5043142-A

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filingDate 1987-10-29^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1991-08-27^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b00fc202f7ba7bb2114ed7ec1a95fa9b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_364e371f3f963226de550b18bd2a6094
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publicationDate 1991-08-27^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5043142-A
titleOfInvention Alpha-hydroperoxyisopropylphenyl compounds and process for preparing the same
abstract PCT No. PCT/JP87/00831 Sec. 371 Date Nov. 17, 1989 Sec. 102(e) Date Nov. 17, 1989 PCT Filed Oct. 29, 1987 PCT Pub. No. WO88/03134 PCT Pub. Date May 5, 1988. alpha -Hydroperoxyisopropylphenyl compounds are useful as an organic hydroxyperoxide content in test compositions for the measurement of peroxide-active substances and are effectively utilized for detecting peroxide-active substances such as blood or hemoglobin (occult blood). Test devices for the detection of occult blood are constituted of a carrier in which organic hydroperoxide, coloration indicator, buffering agent, wetting agent, activating agent and stabilizer are impregnated. If hemoglobin is present in a specimen, the organic hydroperoxide is activated to produce nascent oxygen with which the indicator is oxidized and develops color. Although 2,5-dimethylhexane-2,5-dihydroperoxide and cumene hydroperoxide have been employed as the organic hydroperoxide, they are disadvantageous in remarkable reduction of the detective sensitivity due to lack of the stability with elapse of time, pseudonegative judgement when vitamin C is contained in urine specimen, reduction of capacity in the multi-item test pieces for the detection of urinary components caused by discoloration of the adjacent test pieces, low coloration sensitivity, etc. The compounds of the present invention are improved in the above-mentioned defects. As typical examples of the alpha -hydroperoxy-isopropylphenyl compounds according to the invention are mentioned 4-(2,4,7-trioxaoctyl) cumene hydroperoxide, 4-( alpha -operoxyisopropyl)benzyl benzyl ether, 4-octyl cumene -hydroperoxyisopropyl)benzyl benzyl ether, 4-octyl cumene hydroperoxide, bis[4-( alpha -hydroperoxyisopropyl)benzyl]ether, N,N-dimethyl-]4-( alpha -hydroperoxyisopropyl)benzene]-sulfoamide and the like.
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