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filingDate 1987-07-15^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1991-10-01^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1991-10-01^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5053226-A
titleOfInvention Monoclonal antibodies binding platinum complexes
abstract The present invention relates to monoclonal antibodies specifically binding platinum (II) complex. The monoclonal antibodies of the present invention are characteristically produced by antibody-producing cell lines such as hybridomas. These cell lines may result, for example, from fusion of a neoplastic cell with an antibody-producing animal cell obtained from an animal immunized against a platinum (II) complex. The cellular fusion products include cell lines forming monoclonal antibody specifically binding platinum (II) complex in competition with an antibody produced by: hybridoma strain 1C1H2A5, deposited with the American Type Culture Collection, Rockville, MD on May 1, 1987 and having ATCC accession number HB 9411; strain 3A2A1; strain 1A6A2; strain 3A6B1 or strain 1B1. The cell lines of the present invention are preferably continuous murine hybridoma cell lines which secrete recoverable quantities of monoclonal antibody, particularly a monoclonal antibody which is of an IgG or IgM isotype.
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