| abstract |
compound of the formula: ##STR1## wherein A is the group of the formula: n n Ar.sup.1 --D--Ar.sup.2 -- n n wherein Ar 1 is a phenyl or thienyl group which may be optionally substituted with at least one of the same or different halogen atom; Ar 2 is a phenylene or thienylene group which may be optionally substituted with at least one of the same or different halogen atom; D is a divalent radical selected from the group consisting of >═N═OR 4 [wherein R 4 is a hydrogen atom or lower alkyl group], >C═O, ##STR2## >CHOH, >NH radical, or single bond, wherein R 5 is a lower alkoxy or a phenyl group which may be optionally substituted with at least one of the same or different halogen atom; E is a methine group or a nitrogen atom; F is a vinylene group or an oxygen atom, ##STR3## wherein R 6 is a lower alkoxy group; R 7 is a lower alkyl group; R 8 is a benzoyl group which may be optionally substituted with at least one of the same or different halogen atom, n B is a divalent azole group; n R 1 is a hydrogen atom or a lower alkyl group; n R 2 is a hydrogen atom, lower alkyl aryl-lower alkyl, or the group of the formula: n n R.sup.9 --G-- n n wherein R 9 is a hydrogen atom, lower alkyl, halo-lower alkyl, amino-lower alkyl, aryl or aryl-lower alkyl group or the group of the formula: ##STR4## wherein R 10 is a hydrogen atom or lower alkyl group; R 11 is a hydrogen atom, lower alkyl, lower alkenyl, lower cycloalkyl, aryl-lower alkyl, aryl or aroyl group; or the group of the formula: --NR 10 R 11 is a 5-, 6- or 7-membered saturated heterocyclic ring; or the group of the formula: n n R.sup.12 --O-- n n wherein R 12 is a lower alkyl or polyhalo-lower alkyl group; n G is a divalent group selected from the group consisting of >C═O, >C═S, >(C═O) 2 or >SO 2 radical; or the group of the formula: --NR 1 R 2 is a 5-, 6- or 7-membered saturated heterocyclic ring: n R 3 is a hydrogen atom or lower alkyl group, or its acid addition salts, which is useful for immunomodulator. |