| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_652f577940a3c17d7795b5af0c58d6c7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3891 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 |
| filingDate |
1989-06-21^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1991-12-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea6da8d5b74f293de5285234f7b254e9 |
| publicationDate |
1991-12-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5072032-A |
| titleOfInvention |
Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid |
| abstract |
Methods for converting phosphonates into thiohosphonates and specific thiophosphonate compounds so produced are disclosed and claimed. The methods start with a reaction mixture formed of a phosphonate compound, including one or more strong electron-withdrawing groups located adjacent to the phosphorus in the compound, a slight excess of Lawesson's reagent, and a polar aprotic solvent. The reaction mixture is heated until reaction is complete and may be followed with separation or hydrolyzation steps to produce thiophosphonic acids and their addition salts. One of these thio-analogues, thiophosphonoformic acid (TPFA) is particularly effective at inhibiting HIV replication and in treating mammals infected with HIV. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5463092-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010099869-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009291908-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6943267-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5696277-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517858-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6002029-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6284909-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005049431-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6444837-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6147244-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6441214-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8884011-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5744461-A |
| priorityDate |
1989-06-21^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |