| abstract |
7-Oxabicycloheptane substituted prostaglandin analogs useful in treating thrombotic and vasopastic disease have the structural formula <IMAGE> wherein m is 1, 2 or 3; n is 1, 2, 3 or 4; Z is -(CH2)2-, -CH=CH- or <IMAGE> wherein Y is O, a single bond or vinyl, with the proviso that when n is 0, if Z is <IMAGE> then Y cannot be O, and Z is -CH=CH-, n is 1, 2, 3 or 4; and when Y=vinyl, n=0; R is CO2H, CO2lower alkyl, CH2OH, CO2alkali metal, CONHSOR3, CONHR3a or -CH2-5-tetrazolyl, X is O, S or NH; and where R1, R2, R3 and R3a are as defined herein. |