| abstract |
An excipient for a pharmaceutical compound which melts at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: -Low MW Polyethylene glycol 75-90% -(M.P. about 37 DEG C.) -Medium to high MW polyethylene glycol 0-4% -Long chain saturated carboxylic acid 0-4% -Polyethylene oxide 0-4% -(MW 100,000-5,000,000) -Colloidal silica 10-20%. - The excipient is particularly advantageous for the preparation of dosage forms for buccal administration of pharmaceutical compounds. |