| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6596
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65031
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-301
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6506
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5728 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6596
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6503
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6506 |
| filingDate |
1992-12-07^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1993-12-28^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_163ccbefe295f507185938ba76b1022f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9445d1df74b841ddcbfb9c576845b309 |
| publicationDate |
1993-12-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5274155-A |
| titleOfInvention |
Intramolecular arbuzov process for the preparation of intermediates useful in the preparation of phosphorus containing HMG-COA reductase inhibitors |
| abstract |
A process for the preparation of compounds of formula ##STR1## and pharmaceutically acceptable salts thereof; wherein X is --CH 2 --, --CH 2 CH 2 --, --CH 2 CH 2 CH 2 --, --CH═CH--, --C.tbd.C-- or --CH 2 O-- (where O is linked to Z); Z is a hydrophobic anchor R 1 is hydrogen, alkyl, cycloalkyl or aryl; comprising the steps of: n (A) reacting a compound of formula ##STR2## with a compound of formula ##STR3## or a compound of formula ##STR4## in the presence of an amine base or an alkali metal hydride in an organic solvent to form a compound having the formula ##STR5## (B) heating the compound of formula IX at a temperature of from about 100° C. to about 200° C., to form a compound of formula ##STR6## and (C) quenching the compounds of formula VIII with an acid provides the compounds of formula I. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6365186-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002155091-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7638524-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6264938-B1 |
| priorityDate |
1992-12-07^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |