| abstract |
An optically active N-(meth)acryloyl amino acid amide of the formula <IMAGE> (I) in which R is hydrogen or methyl, R1 represents an optionally substituted alkyl, cycloalkyl, aralkyl, aryl or heteroaryl radical, R3 represents hydrogen or denotes together with R1 a tri- or tetramethylene group; X denotes oxygen or a NR4-group wherein R4 represents hydrogen or alkyl or denotes together with R2 and the nitrogen atom a 5- to 7-membered ring which ring is optionally substituted by the group COO-alkyl (1-6 carbon atoms) or by one or two alkyl radicals (1-4 carbon atoms) and R2 denotes a strongly space-filling hydrocarbon radical. The amide is polymerized and optionally bound to a support such as silica, and can then be used for the chromatographic separation of racemic mixtures of pharmacologically active compounds. |