| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e93d357c3fcb571238ff08afe6072cd |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
1989-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1995-01-24^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08d2cccf6f505c4b1b1cc37dced9b641 |
| publicationDate |
1995-01-24^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5384108-A |
| titleOfInvention |
Magnetic resonance imaging agents |
| abstract |
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. The complexes are represented by the formula of: <IMAGE> wherein A is -CHR2-CHR3- or <IMAGE> M+Z is a paramagnetic ion of an element with an atomic number of 21-29, 42-44 58-70, and a valence, Z, of +2 or +3; R1 groups may be the same or different and are selected from the group consisting of -O- and <IMAGE> The R4, R5 and R6 groups are as defined in the disclosure. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003202943-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5843399-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6565830-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6660246-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005227294-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5859214-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010304404-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5651954-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5663307-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006121544-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7074387-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7745142-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7297702-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004249586-A1 |
| priorityDate |
1989-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |