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filingDate 1993-03-03^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1995-04-04^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5403919-A
titleOfInvention Method to control leukocyte extravasation
abstract Novel antibodies that recognize endothelial cell surface molecules and block leukocyte extravasation are provided. These antibodies recognize tissue-specific endothelial cell surface molecules and block lymphocyte migration from the blood into tissues such as mucosal lymphoid organs and peripheral lymph nodes. Novel endothelial cell surface proteins involved in leukocyte extravasation and having a molecular weight of approximately 58,000 to 69,000 daltons and express a tissue-specific determinant are also described. The antibodies are used in an immunotherapeutic method to treat individuals having a disease or inflammation-associated pathology in which leukocyte extravasation plays a role.
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