| abstract |
Immunomodulatory macrocyclic compounds having the formula: <IMAGE> and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein R8 and R9 are selected such that one of R8 and R9 is hydrogen, and the other is chosen from the group consisting of: (1) -OC(=NR10)-NHR10; (2) -OC(=O)-R11; and (3) -OC(=O)-NR12R13; (4) -OC(=O)-N(OR14)R12; (5) -OC(=O)-NHNR12R13; (6) -OC(=O)-NH-NHC(=O)-NR12R13; (7) -OC(=O)-NH-NHS(O)2-NR12R13; and (8) -OC(=O)-NH-NHC(=NR21 )-NR12R13. as well as pharmaceutical compositions containing such compounds and methods for their use in immunosuppressive, antimicrobial, antifungal, antiviral, antiinflammatory and antiproliferative therapy. |