| abstract |
Novel compounds having the formula <IMAGE> and the pharmaceutically acceptable salts, esters and amides thereof, wherein A is -O-, -S- or -CR2R8-; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X and Y are specifically defined; and up to one combination of (a) R2 and R5, (b) R5 and R6, (c) R5 and R7, (d) R6 and R7, and (e) R7 and Y, taken together with the atoms to which they are attached, may form a ring, the compounds being useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders. Also disclosed are intermediates and processes useful in the preparation of the above compounds. |