| abstract |
New nonionic radiographic contrast agents having the formula ##STR1## wherein Y is a single bond, --CH 2 CH 2 --, --CH 2 O--, --OCH 2 --, ##STR2## --CH 2 --, --CH 2 --CH 2 --CH 2 --, --O-- or ##STR3## R 1 , R 1 ' and R 2 are the same or different and are hydrogen, alkyl or hydroxyalkyl. n Hydroxyalkyl refers to such alkyl groups having 1 or more hydroxy groups. Preferred hydroxyalkyl groups include: ##STR4## R 3 and R 4 are the same or different and are hydrogen, methyl or --CH 2 CH 2 OH; R 5 is hydrogen, alkyl, --CH 2 CH 2 OH, CH 2 OH or OH and R 6 is alkyl, CH 2 CH 2 OH, CH 2 OH, OH or hydrogen and may be the same or different than R 5 and m is zero or one, with the proviso that no methylene or methine carbon atom of the heterocyclic ring is attached to both a nitrogen and an oxygen atom with the additional proviso that when Y is a single bond, m is not zero. n These new contrast agents are water soluble and have desirable low osmolality and anticoagulant properties. |