http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5648228-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_850a17186ff51f03c607cf42a534a635 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2337-12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-86 |
| filingDate | 1994-08-04^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-07-15^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68e2503c8ee30709e40a15919d0a1bf9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4608dc0a8768d6c235bd92a886785452 |
| publicationDate | 1997-07-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5648228-A |
| titleOfInvention | Measuring activity toward production of activated blood coagulation factor XII, plasma kallikrein or bradykinin using reconstituted kallikrein-kinin system |
| abstract | The present invention provides a method for measuring the activity of tested substances utilizing a reconstituted plasma kallikrein-kinin system. A series of enzymatic reactions is started wherein an activation of a blood coagulation factor XII is an initiating reaction. The series of reactions is started in the presence of the tested substance in the reconstituted plasma kallikrein-kinin system. Then, the series of reactions is stopped and the physiologically active substance produced in the reaction series is quantitatively determined. In the activity measuring method of the present invention, the real activity (a promoting or inhibiting ability) of the tested substance against the production of the produced physiologically active substance can be easily, simply, quickly and precisely measured. In the reconstituted plasma kallikrein-kinin reaction system the contaminating other factors are substantially removed. Accordingly, the method of measuring the activity in accordance with the present invention is a very advantageous means for ascertaining action which is useful for adjusting the bioregulations in, for example, the plasma kallikrein-kinin system, the blood clotting system, the fibrinolysis system, etc. It may also be used for developing or screening drugs which are related to the systems. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6117648-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002132370-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6632678-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6913900-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003049713-A1 |
| priorityDate | 1993-08-06^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 80 of 80.