| abstract |
This invention provides a compound having the structure: <IMAGE> wherein each R1, R2, R3, and R4 is independently fluorine, OH or H; Z is O, CH2 or CF2; each Y is independently OH or F; X7 is N or CH, X8 is NH, S or Se; and W is C or N, wherein when W is C, the dashed line (---) represents a double bond and X9 is N or CH, and wherein when W is N, the dashed line (---) represents a single bond and X9 is S or Se, or the dashed line (---) represents a double bond and X9 is N or CH. This invention also provides a pharmaceutical composition comprising the compounds and methods of treating a mammal having an inosine monophosphate dehydrogenase associated disorder. |