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filingDate 1993-12-20^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1998-05-12^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8171b910d11e8278af6b1303da027c4
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publicationDate 1998-05-12^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5750555-A
titleOfInvention Bis-indolyl maleinimide or indolopyrrolo carbazole containing an amino acid as PKC inhibitors
abstract PCT No. PCT/EP93/03611 Sec. 371 Date Nov. 15, 1996 Sec. 102(e) Date Nov. 15, 1996 PCT Filed Dec. 20, 1993 PCT Pub. No. WO94/14798 PCT Pub. Date Jul. 7, 1994The instant invention is a compound of formulaA-X-Y-En-R5in which A is a bis-indolylmaleinimide or indolopyrrolocarbazole useful in the treatment and/or prevention of cancer, viral diseases, thrombosis, heart rhythm disturbances, atherosclerosis, bronchopulmonary diseases, degenerative diseases of the central nervous system, inflammatory diseases, diseases of the immune system, psoriasis, and immune suppression. A pharmaceutical composition and methods of preparing the compounds are also included.
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