| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C403-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C11C3-00 |
| filingDate |
1995-08-22^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-09-15^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c281f415e8eca6ccd916d8a7744d004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73d55f8bc87aab304dfa4229c7cba80c |
| publicationDate |
1998-09-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5808120-A |
| titleOfInvention |
Method of synthesis of retinoic acid |
| abstract |
A method of synthesizing 9-cis-retinoic acid, all-trans-retinoic acid or 9-nor-retinoic acid is disclosed. The method comprises the steps of adding a Grignard reagent of ##STR1## to 2,2,6 trimethyl cyclohexanone is disclosed. R is a methyl group or H and the CH 2 --OH group is in either the cis or trans orientation relative to the HC.tbd.C- group. The resulting product is converted into retinoic acid. In the preferable form of the present invention, a tritium-labelled retinoic acid is synthesized, wherein the labelling is at the C 20 position. A preparation of tritium-labelled 9-cis-retinoic acid with a specific activity of greater than 65 Ci/mmol is also enclosed. In a most preferred embodiment, the specific activity is greater than 75 Ci/mmol. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011195941-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003162823-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004509073-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8404667-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8283481-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2591769-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7265143-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010160166-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008261925-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0203912-A3 |
| priorityDate |
1995-08-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |