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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62cf6886e95fdddf7fc9be7016933946
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publicationDate 2000-08-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6110745-A
titleOfInvention Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
abstract This invention relates to a novel Solvent Extraction and Direct Hydration (SEDH) method for preparing lipid-nucleic acid particles which are useful for the introduction of nucleic acids (e.g., plasmid DNA, antisense molecules, ribozymes, etc.) into cells. The lipid-nucleic acid particles prepared using the methods of the present invention have enhanced circulation characteristics and serum stability and, thus, they are extremely effective as nucleic acid delivery vehicles.
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