| abstract |
The invention concerns a method for preparing microcapsules containing an active substance coated with a substantially polar polymer film, characterized in that it consists in the following steps: suspending an active substance insoluble in a substantially polar polymer solution in an organic solvent, said substantially polar polymer being insoluble in liquid or supercritical CO2, said organic solvent being soluble in liquid or supercritical CO2; contacting the suspension with liquid or supercritical CO2 so as to extract the solvent from the polymer in a controlled manner and ensure the coacervation of the polymer; substantially extracting the solvent by means of supercritical CO2 and draining off the CO2/solvent mixture; recuperating the microcapsules in the form of dry powder. The invention also concerns microcapsules containing an active substance coated with a substantially polar polymer selected among the group consisting of polysaccharides, cellulose derivatives, acrylic, methacrylic polymers or derivatives of esters of vinyl, polyesters, polyamides, polyanhydrides, polyorthoesters and polyphosphazenes, characterized in that the polymer film has low surface energy and is free from organic solvent and in that the microcapsules are obtainable by said method. |