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filingDate 1999-05-10^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2001-06-26^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6251614-B1
titleOfInvention Rapid methods for identifying modifiers of cellular apoptosis activity
abstract The invention provides a single-well, microscale method of determining the specific apoptotic activity of a cell. The method consists of contacting a cell population of about 1x105 cells for a time period of between about 30 minutes and 4 hours with a sufficient volume of medium containing an apoptotic specific diagnostic reagent and a diagnostic accessory reagent so as to cover the cell population, and determining the activity of the apoptotic specific diagnostic reagent. The invention also provides a method of identifying a compound which induces apoptosis. The invention further provides a rapid method of identifying a compound which inhibits apoptosis.
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