| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
1997-08-11^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-07-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20d843111a59da2d22e4f23067e4ef87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dc083e58808b688fa9e29c1e962a498
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2648f8ab5e8256ff9ae7d72ecfcd834c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1e4ccab112c69c9ee1db7759e870604
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3677b6fbc4e7b1b562e0ee597f1883eb |
| publicationDate |
2001-07-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6258555-B1 |
| titleOfInvention |
DNA encoding ACV synthetase |
| abstract |
DNA encoding the gene for the synthetase enzyme capable of generating delta (L-a-aminoadipyl)-L-crysteinyl-D-valine (ACV) from its constituent amino acids was obtained from several penicillin and cephalosporin producing organisms, e.g. Penicillium chrysogenum, cephalosporium and a Flavobacterium species. The DNA was used to prepare recombinant vectors comprising the ACV synthetase gene and hosts transformed with such vectors. The ACV synthetase gene can form part of a gene cluster comprising other genes involved in -beta-lactam biosynthesis and the production of penicillin by expression of the entire biosynthetic gene cluster for the synthesis of penicillin from primary amino acids is described. Suitable hosts in which expression can take place include heterologous hosts which are naturally non-producers of penicillin. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004029108-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008131925-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7141385-B2 |
| priorityDate |
1987-12-09^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |