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filingDate 2000-11-27^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2001-11-06^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fd6c38ba0641abdfb87fd151e0f4e33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efddc8a7e533280aa445d2888e8e76fb
publicationDate 2001-11-06^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6313156-B1
titleOfInvention Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors
abstract Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
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