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filingDate 1999-10-28^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2002-02-12^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6346247-B1
titleOfInvention Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies
abstract The prevention and treatment of autoimmune disease in humans (as well as other animals) is described through the use of ligands directed to cytokines. Antibodies and receptors to the proinflammatory cytokines IL-2, TNF, IL-12 and IFN-gamma are employed (along with other ligands to such cytokines). Such ligands administered luminally are effective (as demonstrated in two experimental models of autoimmune disease) at delaying the onset of autoimune disease.
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