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filingDate 1999-12-10^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2002-04-30^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5f2e12e6f192df7dbe94491a4439bf4
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publicationDate 2002-04-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6379928-B1
titleOfInvention Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
abstract Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence. Preferably functional polyadenylation sequences are operably linked to the 3' terminus of the DNA sequence encoding the heterologous polypeptides. Each of the above described vectors are used in novel processes to transform a filamentous fungus wherein the DNA sequences encoding the signal sequence and heterologous polypeptide are expressed. The thus synthesized polypeptide is thereafter secreted from the filamentous fungus.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1JME5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6J1D4
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID18475210
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5XKU3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8UFR5
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1261044
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1FPC5
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID69711
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3PBA5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5X7S5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1VYA1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9A9R9
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID711845
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5XCT7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8X5X7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9MS23
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID877794
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5XNE4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1MHI1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP00582
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1L005
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9B3N9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5F7D7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2U2Z2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7NS27
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID885074
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP00634
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7GRK8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8RAE4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO05949
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8D7G7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ1CU96
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID22247
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP07683
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419517445
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BE04
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA5I6W8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO50607
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC3KXD9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6I9Z7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3QID1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2S9C4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5SIL5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5FJ82
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ2YNP1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC0HJE2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2RME4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB5FC62
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID439709
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0XZU3
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419479022
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC1FLB3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0U1D6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0XQT1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8RH64
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP08019
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3CZT7
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226399946
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID947
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP14017
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO74110
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9JZC0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ3Z247
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1GZJ3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3LYE4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ5V145

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