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filingDate 2000-08-29^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2002-07-02^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_480514f3fbcbb4369999a7af62dc281e
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publicationDate 2002-07-02^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6414122-B1
titleOfInvention Bifunctional boronic compound complexing reagents and complexes
abstract Embodiments include reagents to modify a bioactive species for incorporating a bifunctional boronic compound complexing moiety for subsequent conjugation to a different or same bioactive species having pendant phenylboronic acid moieties of General Formula I,wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the putative bifunctional boronic compound complexing reagent with a bioactive species, wherein group R2 is selected from one of H and OH moieties, and wherein group R3 is selected from one of an alkyl and a methylene bearing an electronegative substituent. Group Z is a spacer selected from (CH2)n and CH2O(CH2CH2O)n2, wherein n is an integer of from 1 to 5, and wherein n2 is an integer of from 1 to 4. Group Z2 and Z3 is a spacer and need not be the same.
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