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filingDate 1999-02-18^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2003-03-04^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6528059-B1
titleOfInvention Thyroid peroxidase epitopic regions
abstract Specific epitopic regions of thyroid peroxidase (TPO), a thyroid specific membrane autoantigen, have been identified within amino acid residues 456 to 933, 457 to 633, 513 to 633, and 633 to 933 of the protein (SEQ ID NO:2), with at least one distinct binding region within TPO located from amino acid residues 592 to 613 (SEQ ID NO:7). The identification and production of these localized epitopes/epitopic regions provide specific therapeutic reagents for administration to autoimmune thyroid disease patients.
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