| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20 |
| filingDate |
2002-05-10^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-03-04^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7019e5a2d6600e9d9e661ffc343315f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a374284481e9c3dbafa98e59daea5ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf4a7dea66bb0042491da291f92d258c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27263ba95aaed0a09b1dc14286164fd1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66592e52bd5ff4e9702d3c744de8d420 |
| publicationDate |
2003-03-04^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6528091-B1 |
| titleOfInvention |
Controlled release formulation of divalproex sodium |
| abstract |
A controlled release tablet formulation which permits once daily dosing in the treatment of epilepsy comprises from about 50 weight percent to about 55 weight percent of an active ingredient selected from the group consisting of valproic acid, a pharmaceutically acceptable salt or ester of valproic acid, divalproex sodium, and valpromide; from about 20 weight percent to about 40 weight percent hydroxypropyl methylcellulose; from about 5 weight percent to about 15 weight percent lactose, from about 4 weight percent to about 6 weight percent microcrystalline cellulose, and from about 1 weight percent to about 5 weight percent silicon dioxide having an average particle size ranging between about 1 micron and about 10 microns; all weight percentages based upon the total weight of the tablet dosage form. Also disclosed are pre-tableting granular formulations, methods of making the granular formulations and tablets, and a method of treating epilepsy employing the controlled release tablet formulations of the invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011065719-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003211148-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002025341-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005196439-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003206978-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012150607-A2 |
| priorityDate |
1998-12-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |