| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-525 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 |
| filingDate |
2000-03-30^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-05-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6660a9704ac35849b1f9dbdeb4783cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24421aaae24f9453ddeac6cb1789e945
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_067a2146f4008f99d8be75dc102b4c60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f33265de87734c8708a628a28da0be27 |
| publicationDate |
2003-05-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-6566500-B1 |
| titleOfInvention |
Compositions and methods for modifying toxic effects of proteinaceous compounds |
| abstract |
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9921220-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010256070-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009221500-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009010966-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008011157-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009156502-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7829668-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8048985-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008241191-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8323665-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009041797-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470314-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8524241-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10059750-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006100135-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004009148-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865866-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7452971-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006159708-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7157562-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9310369-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8252897-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9134303-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9989529-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009014835-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7585942-B2 |
| priorityDate |
1999-03-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |