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filingDate 2001-08-21^^<http://www.w3.org/2001/XMLSchema#date>
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publicationNumber US-6573270-B1
titleOfInvention Pyrazoles
abstract Compounds of formulae (IA) and (IB):wherein R1, R2, R3, Ar1 and X are as defined above, are endothelin antagonists. The compounds are therefore useful in the treatment of a variety of conditions mediated by endothelin, such as restenosis, renal failure and systemic and pulmonary hypertension.
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