http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6610508-B1

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filingDate 1999-03-08^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2003-08-26^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a0af3e3446c65abb67cca9910bafb38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0533b4b40be19249c25ab830cf04f46
publicationDate 2003-08-26^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6610508-B1
titleOfInvention Translation driver system and methods for use thereof
abstract The present method relates to the translational activation of genes using the ribosome recruitment protein, eIF4G or an eIF4G-like protein. The invention relates to the translation of RNA molecules containing heterologous protein-binding sites, which RNA molecules encode one, two, three or more proteins. The invention provides products and methods for the identification of RNA-binding proteins. The invention further provides a system by which protein-protein interactions and inhibitors or enhancers of these interactions may be identified. Further, the invention provides products and methods to provide a cell with one or more therapeutic proteins. The invention provides products and methods for controlling the levels of translation of such proteins. The invention provides products and methods to control the translation and stoichiometry of multiple subunit proteins. The invention provides products for and methods of screening for proteins which interact with an RNA binding site, and methods for identifying RNA binding sites.
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