http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6660865-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c8dbcf50fe783c0e155cbd9cc1d92c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 |
| filingDate | 2001-06-26^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-12-09^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a85e0dcc056160bc26e36a08810b3eee |
| publicationDate | 2003-12-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-6660865-B2 |
| titleOfInvention | Process for the preparation of quinoline derivatives |
| abstract | Compounds of formula (I), wherein R1 is hydrogen or chlorine and R2 is hydrogen, C1-C8alkyl, or C1-C8 alkyl substituted by C1-C6alkoxy or by C3-C6alkenyloxy, can be prepared by: a) introducing the major portion of the amount to be reacted of a compound of formula (II) into a solvent mixture comprising at least one organic solvent capable of forming an azeotrope with water, and at least one aprotic-dipolar solvent; b) metering in an aqueous strong base in an amount equivalent to that major portion of the total amount of the compound of formula (II); c) adding the remaining portion of the amount to be reacted of the compound of formula (II); d) adding a weak base in an amount that is at least equivalent to that remaining portion; e) removing the water from the reaction mixture by azeotropic distillation; f) adding a compound of formula (III), wherein R2 is as defined for formula (I); and g) isolating the resulting compound of formula (I) from the reaction mixture. |
| priorityDate | 2000-06-28^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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