| abstract |
The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk<1 >is C1-6alkanediyl optionally substituted with hydroxy, C1-4alkyloxy or C1-4alkylcarbonyloxy; -Z<1>-Z<2>- is a bivalent radical; R<1>, R<2 >and R<3 >are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R<1 >and R<2 >are on adjacent carbon atoms, R<1 >and R<2 >taken together may form a bivalent radical; R<4 >is hydrogen or C1-6alkyl; A is a bivalent radical of formula -NR<6>-Alk<2>- (b-1), or -Npiperidinyl-(CH2)m (b-2) wherein m is 0 or 1; R<5 >is a radical of formulawherein n is 1 or 2; p<1 >is 0, and p<2 >is 1 or 2; or p<1 >is 1 or 2, and p<2 >is 0; X is oxygen, sulfur or =NR<9>; Y is oxygen or sulfur; R<7 >is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R<8 >is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R<9 >is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R<10 >is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation. |