| abstract |
This invention relates to novel compounds of Formula (I) for use as vascular damaging agents: n n nwherein: X is selected from: —O—, —S—, —S(O)—, —S(O 2 )—, —N(R 4 )— or —N(R 4 )CH 2 C(O)—; R 1 is independently selected from: amino, halo, hydroxy, —OPO 3 H 2 , C 1-4 alkyl, C 1-4 alkoxy, N-C 1-4 alkylamino, N,N-di-C 1-4 alkanoylamino or C 1-4 alkylthio wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified; R 2 is selected from: hydrogen or C 1-4 alkyl; R 3 is selected from: hydrogen or C 1-4 alkyl; R 4 is selected from: hydrogen or C 1-4 alkyl; n is 0, 1 or 2; and p is 0, 1, 2 or 3; or a salt, pro-drug or solvate thereof. The invention also relates to methods for preparing compounds of Formula (I), to their use as medicaments (including methods for the treatment of angiogenesis or disease states associated with angiogenesis) and to pharmaceutical compositions containing compounds of Formula (I). |