| abstract |
The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD—(X—Y—ONH 2 ) n , wherein CD is mono- or polydeoxy α-, β-, or γ-cyclodextrin, carrying in its 6-, 3- and/or 2-position a group containing the aminooxy group, and optionally carrying substituents different from (X—Y—ONH 2 ). Y is a linker group between the aminooxy group and the mono- or polydeoxy-CD group, X is a functional group or an atom necessary to connect the linker Y and the deoxy CD group, or Y is a direct bond when X is a direct bond, and n is ≧1, but ≦24, 21 and 18 for α-, β- or γ-cyclodextrin, respectively, the protected aminooxy derivatives thereof, as well the methods for their preparation and use. |